题  目：Cryptochromes are photolyase-like photoreceptors that regulate

主讲人💗：刘宏涛 研究员 中国科天美上海植物生理生态研究所，国家杰出青年基金获得者，中科院百人计划

主持人💂🏿：许 玲 教授

地  点👩🏽‍🔧：天美娱乐534报告厅

时  间🤸🏼‍♂️：2018年11月9日 上午9：00 

报告内容简介：photomorphogenesis in plants and the circadian clock in plants and animals. CRY2 has been shown to promote FT (FLOWERING LOCUS T) mRNA expression in response to blue light by suppressing the degradation of the CO (CONSTANS) protein and activating CIB1 (CRY2-interacting bHLH1). Although CIB1 and CO are both transcriptional activators of FT, their relationship is unknown. We show that CIB1 promotes FT transcription in a CO-dependent manner, CIB1 and CO physically interact to induce FT transcription together. CRY2, CIB1 and CO proteins form a protein complex in response to blue light to activate FT transcription, and the complex is regulated by the photoperiod and peaks at dusk along with higher FT expression. We also determined that CRY2 was recruited to the FT chromatin by CIB1 and CO and that all three proteins are bound to the same region within the FT promoter. Therefore, there is crosstalk between the CRY2-CO and CRY2-CIBs pathways, and CIB1 and CO act together to regulate FT transcription and flowering.CRY1 interacts with transcription factors PIF4 (PHYTOCHROME-INTERACTING FACTOR 4) to regulate transcription and temperature responses. Whether UVR8 physically interacts with transcription factors to regulate transcription and UV-B responses was not known. We find multiple UVR8-interacting transcription factors and show that UVR8 can regulate gene expression in response to light by directly interacting with transcription factors.

报告人简介：刘宏涛，博士，中科院上海植物生理生态研究所研究员🫰🟨，博士生导师。1998年河北师范大学毕业𓀝，2005年河北师范大学博士毕业后赴美国加州大学洛杉矶分校从事博士后研究⏮。2011年回国在中科院上海生科院植物生理生态研究所建立“光控发育与光信号转导研究组”，2012年入选中科院“百人计划”A类，并获上海市“浦江人才计划”支持🛌🏼，2013年获得国家基金委“优秀青年基金”支持，2018年获得“国家杰出青年基金”。围绕“蓝光信号调控植物发育的分子基础”这一科学问题开展了系统性研究，取得了一系列研究成果👷🏻‍♂️。相关研究成果发表在Science，Developmental Cell, Nature Plants, PNAS，Plant Cell，EMBO Reports, PLoS Genetics，Current Biology，Trends in Plant Science等国际核心期刊上🦌。受The Plant Cell 杂志邀请于2016年1月开始担任该杂志客座编辑（Guest Editor）。获得2014年度美国植物生理学会年会“Women’s Young Investigator Travel Awards (WYITA) for Plant Biology 2014” 奖，2016年中国科天美“百人计划”终期评估中获得优秀♕。现任中国植物生理与分子生物学学会青年委员会副主任➞、 中国植物生理与分子生物学学会女科学家分会理事、Plant Cell杂志客座编辑（Guest Editor）🤙。