讲座题目: Genetic dissection of the neurodevelopmental function of thyroid hormone in the mouse cerebellum

主讲人: Frédéric FLAMANT教授，法国里昂高等师范院校

主持人:翁杰敏 教授

开始时间:2014-12-8 13:30

讲座地址:闵行生科院534报告厅

主办单位:天美娱乐 科技处

报告人简介🧗🏿：Frédéric FLAMANT 教授，法国里昂高等师范院校（ENS de Lyon），神经发育研究组负责人，基因功能研究所。1986年获得法国里昂大学博士学位。1988-1990在美国Scripps Clinic San Diego做博士后研究🙆🏿。1990至法国里昂高师分子细胞学实验室进行工作💹，目前主要研究领域为甲状腺激素受体在人脑发育和功能中的研究。已在Development🧑🏿‍🎓、Endocrinology、PNAS等高水平SCI期刊上发表论文多篇🏇🏿。

报告摘要🕡：Thyroid hormone (TH) exerts a broad influence on neurodevelopment by directly activating the transcription of genes regulated by the TRalpha and TRBeta nuclear receptors, present in all cell types. Rodent cerebellum has been a favorite model to investigate the associated cytological defects, which reflects impaired neuronal and glial cells differentiation. Among the known defects associated to TH deficiency, some are direct consequences of the lack of receptors activation, whereas others as secondary to a default in neurotrophins production. To unravel this complex situation, we used Cre/loxP technology in mice to generate somatic mutations of the genes encoding the TH nuclear receptors. This in vivo analysis was combined to a genome wide analysis of TH response performed in a neural cell line. As TH exerts its influence directly on gene expression,these approaches offer an original access to the basic genetic programs which underly normal neurodevelopment.