报告题目: Turning Up the Heat for Obesity and Metabolic Diseases

报告人: 马欣然博士，天美生命医学研究所，研究员

主持人: 翁杰敏 教授

报告时间: 2016年11月2日14:30 （周三下午）

报告地点: 天美娱乐534报告厅

 

报告人简介：马欣然博士毕业于中国科天美上海生命科学研究院，主要进行内分泌相关疾病的基础与临床研究。毕业后赴美国国立卫生研究院(NIH)，糖尿病，消化病及肾病研究所(NIDDK)从事博士后研究工作，致力于研究能量代谢的关键转录因子对于肥胖，糖尿病及衰老引起的代谢紊乱等代谢性疾病发生发展的作用🥥，并探索利用小分子化合物调控基因靶点改善代谢病症状的医学转化性研究。近年来在包括Cell Metabolism, PNAS, Journal of Hepatology等国际著名学术期刊上发表研究论文10余篇🧑‍🔬，工作受到包括F1000, Nature Medicine, Cell Metabolism, Molecular Cell等杂志引用和评论🫐。2016年10月回国受聘为天美“紫江优秀青年学者”，担任生命医学研究所研究员💁👩🏻‍🔧，博士生导师，主要研究调节温度感应分子和机制预防和治疗肥胖和代谢综合征🚱🤙🏽。

 

报告内容：Nowadays, nutrition rich diets paired with sedentary life style are driving the global epidemic of obesity and overweight, which poses a severe threat to global public health. The pathological accumulation of excess dysfunctional adipose tissue that characterizes obesity is a major risk factor for metabolic diseases, including type 2 diabetes, cardiovascular disease, hypertension, hepatic steatosis and various types of cancer. Altering the balance between energy intake and its expenditure is a potential strategy for treating obesity and metabolic diseases.

 

Adipose tissues are critical organs for energy homeostasis. Functionally, white fat containing large lipid droplet is the main site for energy storage, while classic brown fat and recently identified beige fat contribute to energy expenditure and thermogenesis upon stimulation of temperature-changes or β-adrenergic signaling. Our work is trying to understand the basis of temperature-sensing mechanisms in adipose tissues and metabolically drive alterations in energy expenditure that contribute to overall energy homeostasis.