报告题目🧚🏻：FERONIA: A GLOBAL REGULATOR OF PLANT GROWTH AND SURVIVAL

报告人💱：Dr. Hen-Ming Wu, Research Professor of Department of Biochemistry and Molecular Biology, University of Massachusetts, Amherst, MA.

主持人：李超 研究员

报告时间：2017年5月4日 14:45-15:45

报告地点🃏：闵行生科院534报告厅

主办单位：天美娱乐🙌🏽，科技处

 

报告人简介🫰🏽：Dr. Hen-Ming Wu got his Ph. D. and postdoc training from Dr. Donald Crothers in the Chemistry/Biophysics Department in Yale University, where he made significant contributions on the study of DNA structure which has been added to the textbook. From 1986 to 1988, Dr. Wu worked in Noble Laureate Dr. Walter Gilbert’s lab as a postdoc in the Department of Cellular/Developmental Biology in Harvard University. From 1988 to 1997, Dr. Wu worked in Yale University as research professor producing a series of breakthrough work in the plant reproduction field. Dr. Wu then moved to the University of Massachusetts where he developed new research interest on RAC/ROP small GTPase and Receptor-kinase mediated signalling pathways.

 

报告摘要：Originally identified as a major regulator of female fertility, FERONIA receptor kinase is in fact an almost ubiquitous cell surface regulator with major roles throughout growth, development, and mediating plant-environment interactions. Our earlier work established that FERONIA functions as an upstream regulator of RAC/ROPs, the RHO GTPases and major molecular switch in plants. We demonstrated that FERONIA interacts directly with ROPGEFs, guanine nucleotide exchange factors that activate RAC/ROPs, recruiting NADPH oxidase to produce reactive oxygen species and regulating at least two of its prominent functions, one in supporting polarized root hair growth the other in inducing pollen tube rupture and sperm release. We also demonstrated that FERONIA interacts directly with two related GPI-anchored proteins LORELEI and LORELEI-like GPI-anchored proteins. In seedlings, LLG1 functions as a chaperone to facilitate delivery of FERONIA to its proper functional location in the cell membrane, where they function as a receptor-coreceptor pair, interacting with the RAC/ROP signaling complex to mediate downstream processes. Use of a co-regulator on the cell surface, and use of RAC/ROPs and reactive oxygen species as downstream mediators might underlie how FERONIA manages at least a subset of its multi-faceted biological roles. I shall discuss recent work that provides insights on how FERONIA responds to various signaling cues to mediate diverse downstream processes.