报告题目🤛🏻：Deciphering HOX protein interactomes in development and cancer
报告人🦐：Dr. Samir Merabet, Director of Research class 2, CNRS.
主持人：翁杰敏 教授
报告时间：2017年5月11日13:30-15:00
报告地点🧑🏼🦳：闵行生科院534报告厅
主办单位：天美娱乐🏄🏼♀️，科技处
报告人简介：
2013: Promoted Director of Research class 2 (DR2, CNRS)
2012: Senior Group Leader at the Institute of Functional Genomic (IGFL, Lyon, France)
2009: HDR Diploma (for supervising PhD students). University Aix- Marseille II.
2009: Promoted Researcher class 1 (CR1, CNRS)
2005: Recruited Researcher class 2 (CR2, CNRS)
2002-2005: Post-doctoral Fellow in the laboratory of Pr. Markus Affolter at the Biozentrum (Basel, Suisse).
1998-2002: Ph. D. in Developmental Biology in the laboratory of Dr. Jacques Pradel at the LGPD (Marseille, France).
1992-1998: Diploma (M. Sc.) in Developmental Biology and Genetics, University Aix-Marseille II (Marseille, France).
1996-1997: Military service (civil service in a professional high school).
报告摘要：HOX proteins are evolutionary conserved transcription factors that play key roles for specifying cell fate and morphologies. Mutations affecting the activity of HOX proteinsare also found in a number of pathologies in human, including solid cancers and leukaemia. In contrast to their important role during normal or aberrant development, the molecular mode of action of HOX proteins remains elusive, which is in part due to the difficulty to identify their protein partners. To tackle this issue, we have established Bimolecular Fluorescence Complementation (BiFC) in different model organisms and cancer cell lines. BiFC allows capturing weak and transient protein-protein interactions in live conditions. Here I will present how the analysis of Hox-cofactor interactions in vivo has changed our vision of the molecular properties underlying the formation of protein-protein interaction networks (also called interactomes). I will also describe a recently deposited patent that allows screening any protein-protein interaction of interest by using the human ORFeome in different live cancer cell lines.
